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Tennessee-Tombigbee Waterway Lock E is an access point along the Tennessee-Tombigbee Waterway in Itawamba County, Mississippi. This waterway is a major navigation channel that connects the Tennessee River to the Tombigbee River, offering a scenic route through northeast Mississippi. The Lock E facility provides access to this important inland waterway system, which is maintained for commercial and recreational traffic. Boaters using this access point should be aware of lock operations, as passage through the lock structure is required for navigation along the waterway.